A Clinical Evaluation Comparing the Bioavailability of Two Buffered Vitamin C
Supplements in Healthy, Non-smoking Males
Kirenia Labiste CRC, Samantha Feldman MS, RD, Diane R. Krieger, M.D, Douglas Kalman PhD. Nutrition& Endocrinology, Miami Research Associates, Miami, FL
Purpose: To determine and compare the relative bioavailability of vitamin C (AA) from
Comfort C® (with Bioperine®) and Ester-C® in healthy, nonsmoking, young males.
Methods: Five males (32.0 ± 6.2 years) received a single, 1 gram dose of AA from 2
different AA products in random order, EACH dose preceded by at least 7 days of a low
AA diet. Blood was drawn pre-ingestion and 30, 60, 90, 120, 210 and 240 minutes postingestion
for serum AA analysis by HPLC. Average urine concentrations of AA were
determined by twenty-four hour collection and HPLC analysis.
Results: Weight adjusted AA concentration changes from baseline were significantly
higher with Comfort C than Ester-C at 60 minutes (4.33±1.47 ug/ml vs 1.68±0.90; p=0.043).
Peak AA concentrations tended to be the same between the two products. Urinary AA
concentrations did not differ between treatments.
Conclusions: Although there were no differences in the overall absorption between the
AA products over the 4-hour test period, with Comfort C displaying a faster rate of
absorption than Ester-C.
This study was conducted using the previous product name, Comfort C. The formulation
remains the same but the product name is now Fast-C.
Fast-C™ is a trademark of Alkemy Partners, LLC.
Bioperine® is a registered trademark of Sabinsa Corporation.
Ester-C® is a registered trademark of Oxycal Laboratories, Inc.
A Clinical Evaluation Comparing The Bioavailability Of Three Vitamin C Supplements In
Healthy Non-Smoking Males
Ilka Morales, Samantha Feldman MS, RD, Diane R. Krieger, M.D, Douglas Kalman PhD. Nutrition &
Endocrinology, Miami Research Associates, Miami, FL
Purpose: To determine and compare the relative bioavailability of vitamin C from two
formulations of Comfort C® (with 4.06 mg and 5.36 mg Bioperine®) and Ester-C® in healthy,
non-smoking, young males.
Methods: Ten males (29.7 ± 13.6) received 3 different vitamin C products in random order
preceded by at least 7 days of a low vitamin C diet. Blood was drawn pre-ingestion and
30, 60, 90, 120, 210 and 240 minutes, and 24 hours post-ingestion for serum vitamin C assay.
Twenty-four hour post-test urine concentrations of vitamin C and dihydroascorbic acid
were determined.
Results: Vitamin C concentrations were slightly higher with both formulations of Comfort C
than Ester-C with significant differences between products at the 30 and 60 minute time
points (30 minutes: p<0.001, 0.006 and 60 minutes: p=0.024, 0.018 respectively).
Conclusions: There were no differences in the overall absorption of the 3 vitamin C
products over the 24-hour test period although Comfort C had a faster rate of absorption
than Ester-C.
This study was conducted using the previous product name, Comfort C. The formulation
remains the same but the product name is now Fast-C.
Fast-C™ is a trademark of Alkemy Partners, LLC.
Bioperine® is a registered trademark of Sabinsa Corporation.
Ester-C® is a registered trademark of Oxycal Laboratories, Inc.
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