Ilka Morales, Samantha Feldman MS, RD, Diane R. Krieger, M.D, Douglas Kalman PhD. Nutrition & Endocrinology, Miami Research Associates, Miami, FL

Purpose: To determine and compare the relative bioavailability of vitamin C from two formulations of Comfort C® (with 4.06 mg and 5.36 mg Bioperine®) and Ester-C® in healthy, non-smoking, young males.

Methods: Ten males (29.7 ± 13.6) received 3 different vitamin C products in random order preceded by at least 7 days of a low vitamin C diet. Blood was drawn pre-ingestion and 30, 60, 90, 120, 210 and 240 minutes, and 24 hours post-ingestion for serum vitamin C assay. Twenty-four hour post-test urine concentrations of vitamin C and dihydroascorbic acid were determined.

Results: Vitamin C concentrations were slightly higher with both formulations of Comfort C than Ester-C with significant differences between products at the 30 and 60 minute time points (30 minutes: p<0.001, 0.006 and 60 minutes: p=0.024, 0.018 respectively).

Conclusions: There were no differences in the overall absorption of the 3 vitamin C products over the 24-hour test period although Comfort C had a faster rate of absorption than Ester-C.

This study was conducted using the previous product name, Comfort C. The formulation remains the same but the product name is now Fast-C.
Fast-C™ is a trademark of Alkemy Partners, LLC.
Bioperine® is a registered trademark of Sabinsa Corporation.
Ester-C® is a registered trademark of Oxycal Laboratories, Inc.

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