Kirenia Labiste CRC, Samantha Feldman MS, RD, Diane R. Krieger, M.D, Douglas Kalman PhD. Nutrition& Endocrinology, Miami Research Associates, Miami, FL

Purpose: To determine and compare the relative bioavailability of vitamin C (AA) from Comfort C® (with Bioperine®) and Ester-C® in healthy, nonsmoking, young males.

Methods: Five males (32.0 ± 6.2 years) received a single, 1 gram dose of AA from 2 different AA products in random order, EACH dose preceded by at least 7 days of a low AA diet. Blood was drawn pre-ingestion and 30, 60, 90, 120, 210 and 240 minutes postingestion for serum AA analysis by HPLC. Average urine concentrations of AA were determined by twenty-four hour collection and HPLC analysis.

Results: Weight adjusted AA concentration changes from baseline were significantly higher with Comfort C than Ester-C at 60 minutes (4.33±1.47 ug/ml vs 1.68±0.90; p=0.043). Peak AA concentrations tended to be the same between the two products. Urinary AA concentrations did not differ between treatments.

Conclusions: Although there were no differences in the overall absorption between the AA products over the 4-hour test period, with Comfort C displaying a faster rate of absorption than Ester-C.

This study was conducted using the previous product name, Comfort C. The formulation remains the same but the product name is now Fast-C.
Fast-C™ is a trademark of Alkemy Partners, LLC.
Bioperine® is a registered trademark of Sabinsa Corporation.
Ester-C® is a registered trademark of Oxycal Laboratories, Inc.

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